Renal perfusion imaging with two‐dimensional navigator gated arterial spin labeling. Issue 2 (27th February 2013)

• Record Type: Journal Article
• Authors: Tan, Huan; Koktzoglou, Ioannis; Prasad, Pottumarthi V.
• Is Part Of: Magnetic resonance in medicine. Volume 71:Issue 2(2014:Feb.)
• Page Start: 570
• Page End: 579
• Publication Date: 2013-02-27
• Subjects: Nuclear magnetic resonance -- Periodicals; Electron paramagnetic resonance -- Periodicals; 616.07548
• DOI: 10.1002/mrm.24692
• Languages: English
• ISSNs: 0740-3194

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="mrm24692-sec-0001" sec-type="section"> <title>Purpose</title> <p>To develop a navigator technique enabling free‐breathing acquisition to afford sufficient signal averaging for quantitative renal perfusion measurement using arterial spin labeling MRI.</p> </sec> <sec id="mrm24692-sec-0002" sec-type="section"> <title>Methods</title> <p>A novel two‐dimensional (2D) navigator technique was implemented in concert with flow‐sensitive alternating inversion recovery (FAIR) preparation and true fast imaging with steady precession (True‐FISP) readout. The navigator images were obtained with a low‐resolution fast low angle shot readout at end of each arterial spin labeling acquisition. A retrospective algorithm was developed to automatically detect respiratory motion for selective signal averaging. The 2D navigator‐gated FAIR True‐FISP sequence was performed in ten healthy volunteers and five patients with chronic kidney disease.</p> </sec> <sec id="mrm24692-sec-0003" sec-type="section"> <title>Results</title> <p>Excellent image quality and comparable cortical perfusion rates (healthy: 276 ± 28 mL/100 g/min, patients: 155 ± 25 mL/100 g/min) to literature values were obtained. An average of 3‐fold signal‐to‐noise ratio improvement was obtained in the 2D navigator‐gated approach compared with the breath‐hold acquisition in healthy volunteers. Good image quality was achieved in patients while the results from breath‐hold acquisition were unusable. The quantitative perfusion rates were significantly lower in chronic kidney disease patients compared with the healthy volunteers.</p> </sec> <sec id="mrm24692-sec-0004" sec-type="section"> <title>Conclusion</title> <p>2D navigator‐gated free breathing arterial spin labeling is feasible and is a noninvasive method to evaluate renal perfusion both in healthy subjects and those with chronic kidney disease. Magn Reson Med 71:570–579, 2014. © 2013 Wiley Periodicals, Inc.</p> </sec> </abstract>