Dynamic contrast‐enhanced MRI in mice at high field: Estimation of the arterial input function can be achieved by phase imaging. Issue 2 (25th February 2013)

• Record Type: Journal Article
• Authors: Fruytier, A.‐C.; Magat, J.; Colliez, F.; Jordan, B.; Cron, G.; Gallez, B.
• Is Part Of: Magnetic resonance in medicine. Volume 71:Issue 2(2014:Feb.)
• Page Start: 544
• Page End: 550
• Publication Date: 2013-02-25
• Subjects: Nuclear magnetic resonance -- Periodicals; Electron paramagnetic resonance -- Periodicals; 616.07548
• DOI: 10.1002/mrm.24682
• Languages: English
• ISSNs: 0740-3194

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="mrm24682-sec-0001" sec-type="section"> <title>Purpose</title> <p>Quantitative dynamic contrast‐enhanced MRI requires an accurate arterial input function (AIF). At high field, increased susceptibility effects and decreased longitudinal relaxivity of contrast agents lead to predominant <italic>T</italic><sub>2</sub>* effects in blood vessels, producing a dip in signal during passage of the contrast agent bolus. This study determined phase‐derived AIFs in mice at 11.7 T.</p> </sec> <sec id="mrm24682-sec-0002" sec-type="section"> <title>Methods</title> <p>AIFs were measured in aorta/vena cava for five FBV/N mice and in iliac arteries/veins for five NMRI mice with a fast low angle shot sequence, simultaneously with tumor imaging (temporal resolution: 1.19 s). Gadoterate was injected into the tail vein as a bolus (0.286 mmol Gd/kg). An in vitro study was also performed to calculate the relationship between ΔΦ and gadolinium concentration.</p> </sec> <sec id="mrm24682-sec-0003" sec-type="section"> <title>Results</title> <p>The phantom system confirmed the linear relationship between measured ΔΦ and gadolinium concentration. In vivo, a dip in arterial magnitude signal made it impossible to quantify the AIF. With phase imaging, a clear quantifiable bolus peak was obtained; peak measured concentration in plasma was 4.9 ± 0.9 mM for FBV/N mice and 8.0 ± 0.6 mM for NMRI mice, close to the expected concentration of 6.8 mM.</p> </sec> <sec id="mrm24682-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Phase imaging seems to be an appropriate means to measure the AIF of mice at high field. Magn Reson Med 71:544–550, 2014. © 2013 Wiley Periodicals, Inc.</p> </sec> </abstract>