Protein carbonylation: Proteomics, specificity and relevance to aging. Issue 1 (30th September 2013)

• Record Type: Journal Article
• Authors: Cabiscol, Elisa; Tamarit, Jordi; Ros, Joaquim; Allan Butterfield, D.; Dalle‐Donne, Isabella
• Is Part Of: Mass spectrometry reviews. Volume 33:Issue 1(2014:Jan./Feb.)
• Page Start: 21
• Page End: 48
• Publication Date: 2013-09-30
• Subjects: Mass spectrometry -- Periodicals; 543
• DOI: 10.1002/mas.21375
• Languages: English
• ISSNs: 0277-7037

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="mas21375-sec-0001" sec-type="section"> <p>Detection and quantification of protein carbonyls present in biological samples has become a popular, albeit indirect, method to determine the existence of oxidative stress. Moreover, the rise of proteomics has allowed the identification of the specific proteins targeted by protein carbonylation. This review discusses these methodologies and proteomic strategies and then focuses on the relationship between protein carbonylation and aging and the parameters that may explain the increased sensitivity of certain proteins to protein carbonylation. © 2013 Wiley Periodicals, Inc. Rapid Commun. Mass Spectrom. 33: 21–48, 2014.</p> </sec> </abstract>