Enhancement of the helical content and stability induced in a linear oligopeptide by an i, i+4 intramolecularly double stapled, overlapping, bicyclic [31, 22, 5]‐(E)ene motif. Issue 1 (January 2014)

• Record Type: Journal Article
• Authors: Mazzier, Daniela; Peggion, Cristina; Toniolo, Claudio; Moretto, Alessandro
• Is Part Of: Biopolymers. Volume 102:Issue 1(2014)
• Page Start: 115
• Page End: 123
• Publication Date: 2014-01
• Subjects: Biopolymers -- Periodicals; Peptides -- Periodicals; Spectrum analysis -- Periodicals; 572.33
• DOI: 10.1002/bip.22438
• Languages: English
• ISSNs: 0006-3525

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <p>Two consecutive <italic>i, i</italic>+4 intramolecular, side chain‐to‐side chain, macrocyclizations of different type carried out on a preformed, partially helical peptide result in a largely predominant, double stapled, overlapping, bicyclic [31, 22, 5]‐(E)ene motif. A detailed ECD and NMR conformational study revealed a significant enhancement of the original helical content and stability, accompanied by an increase of the α‐helix amount over that of the 3₁₀‐helix. © 2013 Wiley Periodicals, Inc. Biopolymers (Pept Sci) 102: 115–123, 2014.</p> </abstract>