Multiresponsive polyanionic microgels with inverse pH responsive behavior by encapsulation of polycationic nanogels. Issue 7 (6th November 2013)

• Record Type: Journal Article
• Authors: Knipe, Jennifer M.; Chen, Frances; Peppas, Nicholas A.
• Is Part Of: Journal of applied polymer science. Volume 131:Issue 7(2014:Apr. 05)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2013-11-06
• Subjects: Polymers -- Periodicals; Polymerization -- Periodicals; 668.9
• DOI: 10.1002/app.40098
• Languages: English
• ISSNs: 0021-8995

Abstract

<abstract abstract-type="main"> <title>ABSTRACT</title> <p>Intelligent, stimuli‐responsive hydrogels have great utility in various fields spanning biomedical technology, separations, and catalysis. Their overall response to surrounding fluids may be further tailored to a specific application by incorporation of one or more intelligent responses within one material, known as multiresponsive hydrogels. This is a report on the facile synthesis and characterization of poly(methacrylic acid‐<italic>co‐N</italic>‐vinylpyrrolidone) microgels encapsulating polycationic nanogels (70<bold>–</bold>100 nm) to incorporate inverse pH responsive behavior within a single hydrogel. Potentiometric titration and pH swelling studies reveal a swelling response dependent on both pH and crosslinking agent. Additionally, a protein and a small molecule are loaded and released to evaluate the pH‐dependent binding affinity. Such a material could exhibit unique protein<bold>‐</bold>binding capacity and pH‐responsive behavior for use in separation or drug delivery applications. © 2013 Wiley Periodicals, Inc. J. Appl. Polym. Sci. <bold>2014</bold>, <italic>131</italic>, 40098.</p> </abstract>