PAP/HIP Protein Is an Obesogenic Factor. Issue 2 (25th October 2013)

• Record Type: Journal Article
• Authors: Secq, Veronique; Mallmann, Cecilia; Gironella, Meritxell; Lopez, Belen; Closa, Daniel; Garcia, Stéphane; Christa, Laurence; Montalto, Giuseppe; Dusetti, Nelson; Iovanna, Juan L.
• Is Part Of: Journal of cellular physiology. Volume 229:Issue 2(2014:Feb.)
• Page Start: 225
• Page End: 231
• Publication Date: 2013-10-25
• Subjects: Physiology -- Periodicals; Cell physiology -- Periodicals; 571.6
• DOI: 10.1002/jcp.24438
• Languages: English
• ISSNs: 0021-9541

Abstract

<abstract abstract-type="main" xml:lang="en"> <title>Abstract</title> <sec id="jcp24438-sec-0001" sec-type="section"> <p>In this article we report the obesogenic role of the acute phase protein PAP/HIP. We found that the transgenic TgPAP/HIP mice develop spontaneous obesity under standard nutritional conditions, with high levels of glucose, leptin, and LDL and low levels of triglycerides and HDL in blood. Accordingly, PAP/HIP‐deficient mice are skinny under standard nutritional conditions. We also found that expression of PAP/HIP is induced in intestinal epithelial cells in response to gavage with olive oil and this induction is AG490 sensitive. We demonstrated that incubation of 3T3‐L1 preadipocytes with a low concentration as 1 ng/ml of recombinant PAP/HIP results in accelerated BrdU incorporation in vitro. PAP/HIP‐dependent adipocytes growth is sensitive to the MEK inhibitor U0126. Finally, patients with severe obesity present higher blood levels of PAP/HIP than non‐obese control individuals. Altogether our data suggest that PAP/HIP could be a mediator of fat tissue development, released by the intestine and induced by the presence of food into the gut. J. Cell. Physiol. 229: 225–231, 2014. © 2013 Wiley Periodicals, Inc.</p> </sec> </abstract>