Intravoxel incoherent motion (IVIM) MR imaging of colorectal liver metastases: Are we only looking at tumor necrosis?. Issue 2 (30th May 2013)

• Record Type: Journal Article
• Authors: Chiaradia, Melanie; Baranes, Laurence; Van, Jeanne Tran; Vignaud, Alexandre; Laurent, Alexis; Decaens, Thomas; Charles‐Nelson, Anaïs; Brugières, Pierre; Katsahian, Sandrine; Djabbari, Marjane; Deux, Jean‐François; Sobhani, Iradj; Karoui, Mehdi; Rahmouni, Alain; Luciani, Alain
• Is Part Of: Journal of magnetic resonance imaging. Volume 39:Issue 2(2014)
• Page Start: 317
• Page End: 325
• Publication Date: 2013-05-30
• Subjects: Magnetic resonance imaging -- Periodicals; 616
• DOI: 10.1002/jmri.24172
• Languages: English
• ISSNs: 1053-1807

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jmri24172-sec-0001" sec-type="section"> <title>Purpose</title> <p>To determine if intra‐voxel incoherent motion diffusion‐weighted imaging (IVIM‐DWI) parameters, including free molecular‐based (D) and perfusion‐related (D*, f) diffusion parameters, correlate with the degree of tumor necrosis and viable tumor in colo‐rectal cancer (CRC) metastasis.</p> </sec> <sec id="jmri24172-sec-0002" sec-type="section"> <title>Materials and Methods</title> <p>Fifteen patients referred for resection of liver metastases from CRC were retrospectively included in this Institutional Review Board approved study. An IVIM‐DWI sequence was performed on a 1.5 Tesla MR imaging system, with 10 <italic>b</italic> factors (0, 10, 20, 30, 50, 80, 100, 200, 400 and 800 s/mm<sup>2</sup>). Mean D, D*, f and apparent diffusion coefficient (ADC) values were determined in metastases with a longest diameter above 10 mm. Correlations between the diffusion parameters and the degree of liver tumor necrosis and viable tissue were determined (Spearman).</p> </sec> <sec id="jmri24172-sec-0003" sec-type="section"> <title>Results</title> <p>Correlation between diffusion parameters and histopathological findings was performed in 35 hepatic metastases with a diameter of more than 10 mm (mean size of 17.9 mm; range, 1–68 mm). Both D (r = 0.36; <italic>P</italic> = 0.035) and ADC (r = 0.4; <italic>P</italic> = 0.02) correlated with the degree of tumor necrosis but not with viable tumor.</p> </sec> <sec id="jmri24172-sec-0004" sec-type="section"> <title>Conclusion</title> <p>ADC variation observed in CRC metastases following systemic chemotherapy reflects a specific increase in free‐molecular diffusion (D), in itself correlated to the degree of metastasis necrosis. <bold>J. Magn. Reson. Imaging 2014;39:317–325</bold>. © <bold>2013 Wiley Periodicals, Inc</bold>.</p> </sec> </abstract>