Vessel‐encoded arterial spin labeling (VE‐ASL) reveals elevated flow territory asymmetry in older adults with substandard verbal memory performance. Issue 2 (30th April 2013)

• Record Type: Journal Article
• Authors: Donahue, Manus J.; Hussey, Erin; Rane, Swati; Wilson, Tracy; van, Matthias; Hartkamp, Nolan; Hendrikse, Jeroen; Ally, Brandon A.
• Is Part Of: Journal of magnetic resonance imaging. Volume 39:Issue 2(2014)
• Page Start: 377
• Page End: 386
• Publication Date: 2013-04-30
• Subjects: Magnetic resonance imaging -- Periodicals; 616
• DOI: 10.1002/jmri.24150
• Languages: English
• ISSNs: 1053-1807

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jmri24150-sec-0001" sec-type="section"> <title>Purpose</title> <p>To evaluate how flow territory asymmetry and/or the distribution of blood through collateral pathways may adversely affect the brain's ability to respond to age‐related changes in brain function. These patterns have been investigated in cerebrovascular disease; however, here we evaluated how flow‐territory asymmetry related to memory generally in older adults.</p> </sec> <sec id="jmri24150-sec-0002" sec-type="section"> <title>Materials and Methods</title> <p>A multi‐faceted MRI protocol, including vessel‐encoded arterial spin labeling capable of flow territory mapping, was applied to assess how flow territory asymmetry; memory performance (CERAD‐Immediate Recall); cortical cerebral blood flow (CBF), white matter lesion (WML) count, and cortical gray matter volume were related in older healthy control volunteers (HC; n = 15; age = 64.5 ± 7 years) and age‐matched mild cognitive impairment volunteers (MCI; n = 7; age = 62.7 ± 3.7 years).</p> </sec> <sec id="jmri24150-sec-0003" sec-type="section"> <title>Results</title> <p>An inverse relationship was found between memory performance and flow territory asymmetry in HC volunteers (<italic>P</italic> = 0.04), which reversed in MCI volunteers (<italic>P</italic> = 0.04). No relationship was found between memory performance and cortical tissue volume in either group (<italic>P</italic> > 0.05). Group‐level differences for HC volunteers performing above versus below average on CERAD‐I were observed for flow territory asymmetry (<italic>P</italic> < 0.02) and cortical volume (<italic>P</italic> < 0.05) only.</p> </sec> <sec id="jmri24150-sec-0004" sec-type="section"> <title>Conclusion</title> <p>Findings suggest that flow territory asymmetry may correlate more sensitively with memory performance than CBF, atrophy and WML count in older adults. <bold>J. Magn. Reson. Imaging 2014;39:377–386</bold>. © <bold>2013 Wiley Periodicals, Inc</bold>.</p> </sec> </abstract>