Apparent diffusion coefficient value reflects invasive and proliferative potential of bladder cancer. Issue 1 (15th April 2013)

• Record Type: Journal Article
• Authors: Kobayashi, Shuichiro; Koga, Fumitaka; Kajino, Kohei; Yoshita, Soichiro; Ishii, Chikako; Tanaka, Hiroshi; Saito, Kazutaka; Masuda, Hitoshi; Fujii, Yasuhisa; Yamada, Tetsuo; Kihara, Kazunori
• Is Part Of: Journal of magnetic resonance imaging. Volume 39:Issue 1(2014)
• Page Start: 172
• Page End: 178
• Publication Date: 2013-04-15
• Subjects: Magnetic resonance imaging -- Periodicals; 616
• DOI: 10.1002/jmri.24148
• Languages: English
• ISSNs: 1053-1807

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="jmri24148-sec-0001" sec-type="section"> <title>Purpose</title> <p>To elucidate a role of apparent diffusion coefficient (ADC) value as a biomarker of bladder cancer, we investigated its associations with Ki‐67 labeling index (LI) along with classical clinicopathological prognosticators.</p> </sec> <sec id="jmri24148-sec-0002" sec-type="section"> <title>Materials and Methods</title> <p>Diffusion‐weighted MRI (DW‐MRI) at 1.5 Tesla using <italic>b</italic>‐values of 0, 500, 1000, and 2000 s/mm<sup>2</sup> was prospectively taken before transurethral resection by 132 bladder cancer patients. ADC value of index tumors was measured and compared with clinicopathological prognosticators including Ki‐67 LI.</p> </sec> <sec id="jmri24148-sec-0003" sec-type="section"> <title>Results</title> <p>ADC value was significantly lower in tumors with higher Ki‐67 LIs, sessile tumors (versus papillary), larger tumors, higher grade disease, and higher T stage disease. ADC value inversely correlated with Ki‐67 LI (ρ = −0.57; <italic>P</italic> < 0.0001). On multiple regression analysis, T stage and Ki‐67 LI significantly correlated with ADC value. The Akaike information criterion confirms these two parameters constitute the best model for determining ADC value. Similarly, T stage and ADC value significantly correlated with Ki‐67 LI and these two parameters composed the best model for predicting Ki‐67 LI.</p> </sec> <sec id="jmri24148-sec-0004" sec-type="section"> <title>Conclusion</title> <p>ADC value would reflect T stage and Ki‐67 LI, representing invasive and proliferative potential, respectively. ADC value is likely to serve as a biomarker reflecting aggressiveness of bladder cancer. J. Magn. Reson. Imaging 2014;39:172–178. © 2013 Wiley Periodicals, Inc.</p> </sec> </abstract>