Epilepsy and brain injury: A case report of a dramatic neuropsychiatric vicious circle. (July 2013)

• Record Type: Journal Article
• Authors: Rapinesi, Chiara; Del Casale, Antonio; Serata, Daniele; Kotzalidis, Giorgio D.; Scatena, Paola; Muzi, Antonio; Lazanio, Simone; Savoja, Valeria; Carbonetti, Paolo; Fensore, Claudio; Ferracuti, Stefano; Angeletti, Gloria; Tatarelli, Roberto; Girardi, Paolo
• Is Part Of: Brain injury. Volume 27:Number 7/8(2013)
• Page Start: 940
• Page End: 943
• Publication Date: 2013-07
• Subjects: Brain damage -- Periodicals; Brain -- Wounds and injuries -- Periodicals; Brain Injuries -- Periodicals; 617.481
• DOI: 10.3109/02699052.2013.775489
• Languages: English
• ISSNs: 0269-9052

Abstract

<abstract> <title>Abstract</title> <p> <italic>Primary objective</italic>: Early treatment of epilepsy is warranted to avoid possible severe consequences. This study aimed to assess the value of treatment in a patient who developed epilepsy after major brain surgery.</p> <p> <italic>Design</italic>: Case description. A 51 years-old man had a history of putative petit mal seizures since adolescence and left frontotemporal lobectomy after a major traffic accident at age 17. He subsequently developed quickly generalizing partial complex seizures, associated with severe behavioural alterations and personality changes; the condition was left untreated. A further seizure-related loss of consciousness led to another traffic accident at age 47.</p> <p> <italic>Methods and procedures</italic>: The patient was administered 200 mg/day topiramate, 600 mg/day quetiapine, 1000 mg/day valproate, 1200 mg/day gabapentin and 800 mg/day carbamazepine.</p> <p> <italic>Main outcomes and results</italic>: The instituted anti-epileptic treatment reduced seizure frequency and severity, but did not affect psychiatric symptomatology, which even worsened. An association between anti-epileptic drugs with mood stabilizing properties and an atypical anti-psychotic dramatically improved psychiatric symptoms, but did not prevent the patient from needing long-term healthcare.</p> <p> <italic>Conclusions</italic>: Long-term untreated epilepsy may expose to accident proneness and further psychiatric deterioration. Early diagnosis and treatment of epilepsy may help in avoiding a potentially lethal vicious circle.</p> </abstract>