Alterations in speech and voice in patients with mucopolysaccharidoses. (April 2014)

• Record Type: Journal Article
• Authors: Nakarat, Todsaporn; Läßig, Anne K.; Lampe, Christina; Keilmann, Annerose
• Is Part Of: Logopedics, phoniatrics, vocology. Volume 39:Number 1(2014)
• Page Start: 30
• Page End: 37
• Publication Date: 2014-04
• Subjects: Language disorders -- Periodicals; Speech disorders -- Periodicals; Vocal cords -- Periodicals; Voice -- Periodicals; 616.855
• DOI: 10.3109/14015439.2013.776630
• Languages: English
• ISSNs: 1401-5439

Abstract

<abstract> <title>Abstract</title> <p>The mucopolysaccharidoses are a group of lysosomal disorders characterized by abnormal accumulation of glycosaminoglycans within cell lysosomes leading to a variety of signs and symptoms including alterations in speech and voice production. These changes were analysed in 44 patients with mucopolysaccharidosis (MPS) types I, II, and VI using standardized protocols. Compared to healthy individuals the diadochokinetic rate for the fast repetition of syllables was slower and more irregular, the voice-onset time for the voiceless consonant /p/ was shorter, and most patients had a hoarse voice. The fundamental frequency (F₀) of sustained spoken vowels was in the normal range for most women and children with MPS, but adult males with MPS had a higher F₀ than healthy men.</p> </abstract>