Polycystic ovary syndrome and low-grade inflammation with special reference to YKL-40. (April 2014)

• Record Type: Journal Article
• Authors: Aziz, M.; Wissing, M. L. M.; Naver, K. V.; Faber, J.; Skouby, S. O.
• Is Part Of: Gynecological endocrinology. Volume 30:Number 4(2014:Apr.)
• Page Start: 311
• Page End: 315
• Publication Date: 2014-04
• Subjects: Endocrine gynecology -- Periodicals; Generative organs, Female -- Diseases -- Periodicals; 618.1
• DOI: 10.3109/09513590.2013.879854
• Languages: English
• ISSNs: 0951-3590

Abstract

<abstract> <title>Abstract</title> <p> <italic>Objective</italic>: To evaluate the plasma level of YKL-40 in a Danish polycystic ovary syndrome (PCOS) population and to investigate whether YKL-40 is associated with CVD risk factors such as waist circumference, body mass index (BMI), insulin resistance (IR), fasting glucose, fasting insulin, blood lipids and CRP.</p> <p> <italic>Design</italic>: Cross-sectional study.</p> <p> <italic>Setting</italic>: Gynecological clinics at three Danish University Hospitals<bold>.</bold></p> <p> <italic>Patients</italic>: One hundred seventy-one premenopausal women with PCOS recruited consecutively from April 2010 to February 2012. PCOS was diagnosed according to the Rotterdam criteria.</p> <p> <italic>Main outcome measures</italic>: Plasma level of YKL-40 in four phenotypes of PCOS defined by BMI and IR.</p> <p> <italic>Results:</italic> No statistically significant difference was observed in the plasma level of YKL-40 across the four BMI/IR-phenotypes. Positive associations were observed between YKL-40 and BMI, total and free testosterone, triglycerides, and CRP. Total and free testosterone were independent predictors of YKL-40.</p> <p> <italic>Conclusion</italic>: YKL-40, the marker of low-grade inflammation is not increased in women with PCOS.</p> </abstract>