Pregnancy and perinatal outcomes among women with multiple sclerosis: a retrospective case-controlled study in South Hungary. (April 2014)

• Record Type: Journal Article
• Authors: Vanya, Melinda; Nyari, Tibor; Bencsik, Krisztina; Bartfai, György
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 27:Number 6(2014:Jun.)
• Page Start: 577
• Page End: 581
• Publication Date: 2014-04
• Subjects: Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• DOI: 10.3109/14767058.2013.825596
• Languages: English
• ISSNs: 1476-7058

Abstract

<abstract> <title>Abstract</title> <p> <italic>Objective</italic>: The aim of this study was to investigate the connections between multiple sclerosis (MS) and fertility, pregnancy.</p> <p> <italic>Methods</italic>: The case histories and pregnancy complications in a sample of 65 treatment-naive pregnant women with MS in the period 1998–2012 were compared with an age-matched case-controlled analysis. Comparisons were made between primigravidas and multigravidas subjects.</p> <p> <italic>Results</italic>: Our results revealed a higher rate of miscarriage (18.46%) in the first trimester in women with MS, and intrauterine death (7.69%) in the third trimester, as compared with women without MS (<italic>p</italic> &lt; 0.001 and <italic>p</italic> = 0.035).</p> <p> <italic>Conclusions</italic>: These findings suggest that, the risk of miscarriages and intrauterine death may be disease-related not drug-related feature. Further studies are needed to determine to possible associated factors of miscarriages.</p> </abstract>