Serum level of soluble triggering receptor expressed on myeloid cells-1 as a biomarker of disease activity in relapsing polychondritis. Issue 1 (January 2014)

• Record Type: Journal Article
• Authors: Sato, Tomoo; Yamano, Yoshihisa; Tomaru, Utano; Shimizu, Yukiko; Ando, Hitoshi; Okazaki, Takahiro; Nagafuchi, Hiroko; Shimizu, Jun; Ozaki, Shoichi; Miyazawa, Teruomi; Yudoh, Kazuo; Oka, Hiroshi; Suzuki, Noboru
• Is Part Of: Modern rheumatology. Volume 24:Issue 1(2014)
• Page Start: 129
• Page End: 136
• Publication Date: 2014-01
• Subjects: Rheumatology -- Periodicals; 616.723005
• DOI: 10.3109/14397595.2013.852854
• Languages: English
• ISSNs: 1439-7595

Abstract

<abstract> <title>Abstract</title> <p> <italic>Objectives</italic> We aimed to identify a serum biomarker for evaluating the disease activity of relapsing polychondritis (RP).</p> <p> <italic>Methods</italic> We measured and compared serum levels of 28 biomarkers potentially associated with this disease, including soluble triggering receptor expressed on myeloid cells-1 (sTREM-1), high-sensitivity C-reactive protein (hs-CRP), and cartilage oligomeric matrix protein (COMP), in 15 RP patients and 16 healthy donors (HDs). We divided the 15 RP patients into active RP (<italic>n</italic> = 8) and inactive RP (<italic>n</italic> = 7) groups, depending on the extent of the disease, and compared candidate markers between groups. The localization of membrane-bound TREM-1 in the affected tissue was examined by immunohistochemistry.</p> <p> <italic>Results</italic> Serum levels of sTREM-1, interferon-γ, chemokine (C–C motif) ligand 4, vascular endothelial growth factor, and matrix metalloproteinases-3 were significantly higher in RP patients than HDs. Among these markers, sTREM-1 had the highest sensitivity and specificity (86.7 and 86.7 %, respectively). Furthermore, the serum level of sTREM-1 was significantly higher in active RP patients than inactive RP patients (<italic>p</italic> = 0.0403), but this was not true for hs-CRP or COMP. TREM-1 was expressed on endothelial cells in RP lesions.</p> <p> <italic>Conclusions</italic> The serum level of sTREM-1 may be a useful marker of disease activity in RP.</p> </abstract>