LDL cholesterol: should guidelines include targets?. (March 2014)

• Record Type: Journal Article
• Authors: Banerjee, Subhash; Kahali, Dhiman; Banerjee, Avantika; Brilakis, Emmanouil S
• Is Part Of: Expert review of cardiovascular therapy. Volume 12:Number 3(2014)
• Page Start: 285
• Page End: 290
• Publication Date: 2014-03
• Subjects: Cardiovascular agents -- Research -- Periodicals; 616.12061
• DOI: 10.1586/14779072.2014.874284
• Languages: English
• ISSNs: 1477-9072

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p>Elevated low-density lipoprotein cholesterol (LDL-C) is associated with adverse cardiovascular outcomes. The strategy of target-based LDL-C lowering to reduce the risk of coronary heart disease and secondary event rates is now well established. However, the strategy for treating to a target LDL-C, and whether there is a lower threshold level for LDL-C continues to be debated. We present, and critically analyze the evidence for a target-based LDL-C lowering strategy, and the safety and efficacy of intensive plasma LDL-C-lowering with traditional, and novel LDL-lowering therapies below current guideline targets.</p> </abstract>