DNA-based nanosensors for next-generation clinical diagnostics via detection of enzyme activity. (January 2014)

• Record Type: Journal Article
• Authors: Stougaard, Magnus; Ho, Yi-Ping
• Is Part Of: Expert review of molecular diagnostics. Volume 14:Number 1(2014)
• Page Start: 1
• Page End: 3
• Publication Date: 2014-01
• Subjects: Molecular diagnosis -- Periodicals; 616.0758205
• DOI: 10.1586/14737159.2014.863151
• Languages: English
• ISSNs: 1473-7159

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p>Specific and sensitive detection of DNA-modifying enzymes represents a cornerstone in modern medical diagnostics. Many of the currently prevalent methods are not preferred in the clinics because they rely heavily on pre-amplification or post-separation steps. This editorial highlights the potential of adopting DNA-based nanosensors for the assessment of the activities of DNA-modifying enzymes, with emphasis on the topoisomerase and tyrosyl-DNA phosphodiesterase families. By underlining the existing challenges, we expect that the DNA-nanosensors may soon be promoted to clinical diagnostics via enzyme detection.</p> </abstract>