CYP2A6 Genotype and Smoking Behavior in Current Smokers Screened for Lung Cancer. (28th May 2013)

• Record Type: Journal Article
• Authors: Styn, Mindi A.; Nukui, Tomoko; Romkes, Marjorie; Perkins, Kenneth A.; Land, Stephanie R.; Weissfeld, Joel L.
• Is Part Of: Substance use & misuse. Volume 48:Number 7(2013)
• Page Start: 490
• Page End: 494
• Publication Date: 2013-05-28
• Subjects: Narcotic habit -- Periodicals; Alcoholism -- Periodicals; Substance abuse -- Periodicals; Behavior, Addictive -- Periodicals; Sustance-Related Disorders -- Periodicals; 362.2905
• DOI: 10.3109/10826084.2013.778280
• Languages: English
• ISSNs: 1082-6084

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p>Functional CYP2A6 genetic variation partially determines nicotine metabolism. In 2005, we examined functional CYP2A6 variants associated with reduced metabolism (CYP2A6*2, CYP2A6*9, CYP2A6*4), smoking history, and change in smoking in 878 adult smokers undergoing lung cancer screening in an urban setting. At one year, 216 quit smoking for more than 30 days while 662 continued smoking. Compared to subjects who smoked 30 cigarettes per day at baseline, the odds of a reduced metabolism genotype was 52% higher in subjects smoking 20–29 cigarettes per day and 86% higher in subjects smoking less than 20 cigarettes per day (<italic>p</italic>-trend = 0.016). Reduced metabolism genotypes appeared unrelated to quitting. Though related to smoking dose, CYP2A6 may not influence cessation.</p> </abstract>