Mechanisms of muscle growth and atrophy in mammals and Drosophila. Issue 2 (24th October 2013)

• Record Type: Journal Article
• Authors: Piccirillo, Rosanna; Demontis, Fabio; Perrimon, Norbert; Goldberg, Alfred L.
• Is Part Of: Developmental dynamics. Volume 243:Issue 2(2014:Feb.)
• Page Start: 201
• Page End: 215
• Publication Date: 2013-10-24
• Subjects: Morphogenesis -- Periodicals; Anatomy -- Periodicals; Anatomie -- Périodiques; Biologie du développement -- Périodiques; 571.833
• DOI: 10.1002/dvdy.24036
• Languages: English
• ISSNs: 1058-8388

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <underline>Background:</underline> The loss of skeletal muscle mass (atrophy) that accompanies disuse and systemic diseases is highly debilitating. Although the pathogenesis of this condition has been primarily studied in mammals, <italic>Drosophila</italic> is emerging as an attractive system to investigate some of the mechanisms involved in muscle growth and atrophy. <underline>Results:</underline> In this review, we highlight the outstanding unsolved questions that may benefit from a combination of studies in both flies and mammals. In particular, we discuss how different environmental stimuli and signaling pathways influence muscle mass and strength and how a variety of disease states can cause muscle wasting. <underline>Conclusions:</underline> Studies in <italic>Drosophila</italic> and mammals should help identify molecular targets for the treatment of muscle wasting in humans. <italic>Developmental Dynamics 243:201–215, 2014</italic>. © 2013 Wiley Periodicals, Inc.</p> </abstract>