Association of Incident Symptomatic Hip Osteoarthritis With Differences in Hip Shape by Active Shape Modeling: The Johnston County Osteoarthritis Project. Issue 1 (January 2014)

• Record Type: Journal Article
• Authors: Nelson, Amanda E.; Liu, Felix; Lynch, John A.; Renner, Jordan B.; Schwartz, Todd A.; Lane, Nancy E.; Jordan, Joanne M.
• Is Part Of: Arthritis care & research. Volume 66:Issue 1(2014:Jan.)
• Page Start: 74
• Page End: 81
• Publication Date: 2014-01
• Subjects: Arthritis -- Periodicals; Rheumatism -- Periodicals; 616.72
• DOI: 10.1002/acr.22094
• Languages: English
• ISSNs: 2151-464X

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="acr22094-sec-0001" sec-type="section"> <title>Objective</title> <p>To investigate hip shape by active shape modeling (ASM) as a potential predictor of incident radiographic hip osteoarthritis (RHOA) and symptomatic hip osteoarthritis (SRHOA).</p> </sec> <sec id="acr22094-sec-0002" sec-type="section"> <title>Methods</title> <p>All hips developing RHOA from baseline (Kellgren/Lawrence [K/L] grade 0/1) to mean 6‐year followup (K/L grade ≥2, 190 hips) and 1:1 control hips (K/L grade 0/1 at both times, 192 hips) were included. Proximal femur shape was defined on baseline anteroposterior pelvis radiographs and submitted to ASM, producing a mean shape and continuous variables representing independent modes of shape variation. Mode scores (n = 14, explaining 95% of shape variance) were simultaneously included in logistic regression models with incident RHOA and SRHOA as dependent variables, adjusted for intraperson correlations, sex, race, body mass index (BMI), baseline K/L grade, and/or symptoms.</p> </sec> <sec id="acr22094-sec-0003" sec-type="section"> <title>Results</title> <p>We evaluated 382 hips from 342 individuals: 61% women and 83% white, with mean age 62 years and mean BMI 29 kg/m<sup>2</sup>. Several modes differed by sex and race, but no modes were associated with incident RHOA overall. Among men only, modes 1 and 2 were significantly associated (for a 1‐SD decrease in mode 1 score: odds ratio [OR] 1.7 [95% confidence interval (95% CI) 1.1–2.5] and for a 1‐SD increase in mode 2 score: OR 1.5 [95% CI 1.0–2.2]) with incident RHOA. A 1‐SD decrease in mode 2 or 3 score increased the odds of SRHOA by 50%.</p> </sec> <sec id="acr22094-sec-0004" sec-type="section"> <title>Conclusion</title> <p>This study confirms other reports that variations in proximal femur shape have a modest association with incident hip OA. The observation of proximal femur shape associations with hip symptoms requires further investigation.</p> </sec> </abstract>