Usefulness of 2‐[18F]‐fluoro‐2‐deoxy‐d‐glucose–Positron Emission Tomography/Computed Tomography for Staging and Evaluation of Treatment Response in IgG4‐Related Disease: A Retrospective Multicenter Study. Issue 1 (January 2014)

• Record Type: Journal Article
• Authors: Ebbo, Mikael; Grados, Aurélie; Guedj, Eric; Gobert, Delphine; Colavolpe, Cécile; Zaidan, Mohamad; Masseau, Agathe; Bernard, Fanny; Berthelot, Jean‐Marie; Morel, Nathalie; Lifermann, François; Palat, Sylvain; Haroche, Julien; Mariette, Xavier; Godeau, Bertrand; Bernit, Emmanuelle; Costedoat‐Chalumeau, Nathalie; Papo, Thomas; Hamidou, Mohamed; Harlé, Jean‐Robert; Schleinitz, Nicolas
• Is Part Of: Arthritis care & research. Volume 66:Issue 1(2014:Jan.)
• Page Start: 86
• Page End: 96
• Publication Date: 2014-01
• Subjects: Arthritis -- Periodicals; Rheumatism -- Periodicals; 616.72
• DOI: 10.1002/acr.22058
• Languages: English
• ISSNs: 2151-464X

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="acr22058-sec-0001" sec-type="section"> <title>Objective</title> <p>To evaluate the usefulness of 2‐[<sup>18</sup>F]‐fluoro‐2‐deoxy‐<sc>d</sc>‐glucose–positron emission tomography/computed tomography (FDG‐PET/CT) in IgG4‐related disease (IgG4‐RD) for the staging of the disease and the followup under treatment.</p> </sec> <sec id="acr22058-sec-0002" sec-type="section"> <title>Methods</title> <p>All patients included in the French IgG4‐RD registry who underwent ≥1 FDG‐PET/CT scan were included in the study. Clinical, biologic, pathologic, radiologic, and FDG‐PET/CT qualitative and quantitative findings were retrospectively collected and analyzed.</p> </sec> <sec id="acr22058-sec-0003" sec-type="section"> <title>Results</title> <p>Twenty‐one patients were included in the study and 46 FDG‐PET/CT examinations were evaluated. At either diagnosis or relapse, all evaluated patients presented abnormal <sup>18</sup>F‐FDG uptake in typical IgG4‐RD localizations. In most cases, FDG‐PET/CT was more sensitive than conventional imaging to detect organ involvement, especially in arteries, salivary glands, and lymph nodes. In few cases (small‐sized lesions and brain or kidney contiguous lesions), false‐negative results were noted. Evaluation before and after treatment showed in most cases a good correlation of FDG‐PET/CT results with treatment response and disease activity.</p> </sec> <sec id="acr22058-sec-0004" sec-type="section"> <title>Conclusion</title> <p>This large retrospective study shows that FDG‐PET/CT imaging is useful for the staging of IgG4‐RD. Moreover, FDG‐PET/CT is useful to assess the response to treatment during followup.</p> </sec> </abstract>