Tunable Delivery of siRNA from a Biodegradable Scaffold to Promote Angiogenesis In Vivo. (16th December 2013)

• Record Type: Journal Article
• Authors: Nelson, Christopher E.; Kim, Arnold J.; Adolph, Elizabeth J.; Gupta, Mukesh K.; Yu, Fang; Hocking, Kyle M.; Davidson, Jeffrey M.; Guelcher, Scott A.; Duvall, Craig L.
• Is Part Of: Advanced materials. Volume 26:Number 4(2014)
• Page Start: 607
• Page End: 614
• Publication Date: 2013-12-16
• Subjects: Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.201303520
• Languages: English
• ISSNs: 0935-9648

Abstract

<abstract abstract-type="graphical" xml:lang="en" id="adma201303520-abs-0001"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>A system is engineered for temporally controlled delivery of siRNA</bold> from biodegradable tissue regenerative scaffolds. Therapeutic application of this approach to silence PHD2 promotes expression of pro‐angiogenic genes controlled by HIF1α and enhanced scaffold vascularization in vivo. This technology provides a new standard for efficient and controllable gene silencing to modulate host response within regenerative biomaterials. <boxed-text content-type="graphic" position="anchor" orientation="portrait"><graphic position="anchor" mimetype="image" xlink:href="ark:/27927/pgg40ndjb35" orientation="portrait" xlink:type="simple" xmlns:xlink="http://www.w3.org/1999/xlink" /></boxed-text></p> </abstract>