CA 125 levels and left ventricular function in patients with end-stage renal disease on maintenance hemodialysis. (March 2014)

• Record Type: Journal Article
• Authors: Yilmaz, Hakki; Gürel, Ozgül Malcok; Çelik, Hüseyin Tugrul; Şahiner, Enes; Yildirim, Mehmet Erol; Bilgiç, Mukadder Ayşe; Bavbek, Nuket; Akcay, Ali
• Is Part Of: Renal failure. Volume 36:Number 2(2014)
• Page Start: 210
• Page End: 216
• Publication Date: 2014-03
• Subjects: Chronic renal failure -- Periodicals; Acute renal failure -- Periodicals; Uremia -- Periodicals; 616.614005
• DOI: 10.3109/0886022X.2013.859528
• Languages: English
• ISSNs: 0886-022X

Abstract

<abstract> <title>Abstract</title> <p> <italic>Purpose</italic>: The aim of this study was to analyze associations between serum cancer antigen 125 (CA 125) levels and left ventricular (LV) function in patients with end-stage renal disease on maintenance hemodialysis (HD). <italic>Methods</italic>: CA 125 levels, pro-brain natriuretic peptide (pro-BNP) and biochemical parameters were measured, and echocardiography was performed for 110 patients and 47 healthy controls. <italic>Results</italic>: The mean CA 125 level in patients, 38.78 ± 35.48 U/mL, was significantly higher than that found in healthy controls (9.20 ± 4.55 U/mL; <italic>p</italic> = 0.003). Patients with elevated CA 125 levels (<italic>n</italic> = 40) had significantly lower levels of albumin and reduced relative wall thickness, LV ejection fraction (EF) and fractional shortening but significantly higher levels of pro-BNP and a greater left ventricular end-diastolic diameter (LVEDd) and -systolic diameter (LVESd). CA 125 levels were positively correlated with pro-BNP (<italic>r</italic> = 0.596, <italic>p</italic> < 0.05) and C-reactive protein (CRP) levels (<italic>r</italic> = 0.439, <italic>p</italic> < 0.05), as well as LVEDd (<italic>r</italic> = 0.599, <italic>p</italic> < 0.001), LVESd (<italic>r</italic> = 0.750, <italic>p</italic> < 0.001) and LV mass index (<italic>r</italic> = 0.378, <italic>p</italic> < 0.05). In contrast, serum CA 125 levels were negatively correlated with albumin (<italic>r</italic> = −0.513, <italic>p</italic> < 0.05) and hemoglobin (<italic>r</italic> = −0.475, <italic>p</italic> < 0.05) as well as the EF (<italic>r</italic> = −0.878, <italic>p</italic> < 0.0001). A depressed EF (<italic>β</italic> = −1.121, <italic>p</italic> < 0.0001) and increased CRP levels (<italic>β</italic> = 0.247, <italic>p</italic> = 0.035) were independent predictors of high CA 125 levels in the whole group in the multivariate-model. <italic>Conclusions</italic>: Our study is the first to demonstrate an association between serum CA 125 levels and LV systolic dysfunction <italic>via</italic> inflammation in patients on maintenance HD.</p> </abstract>