Association of the C242T polymorphism in the NAD(P)H oxidase P22 phox gene with type 2 diabetes mellitus risk: a meta-analysis. (March 2014)

• Record Type: Journal Article
• Authors: Sun, Qianqian; Yin, Yanwei; Zhu, Zhiming; Yan, Zhencheng
• Is Part Of: Current medical research and opinion. Volume 30:Number 3(2014:Mar.)
• Page Start: 415
• Page End: 422
• Publication Date: 2014-03
• Subjects: Clinical medicine -- Periodicals; Therapeutics -- Periodicals; 615.5
• DOI: 10.1185/03007995.2013.858620
• Languages: English
• ISSNs: 0300-7995

Abstract

<abstract> <title>Abstract</title> <sec id="ss1"> <title>Objectives:</title> <p>A number of epidemiological studies have explored the association between NAD(P)H oxidase P22 phox gene C242T (rs4673) polymorphism and susceptibility to type 2 diabetes mellitus (T2DM), but the results are still debatable. Therefore, we conducted a meta-analysis to assess the potential association between the NAD(P)H oxidase P22 phox gene C242T polymorphism and T2DM risk.</p> </sec> <sec id="ss2"> <title>Methods:</title> <p>Electronic literature searches of the PubMed, Embase, Web of Science, CBMdisc, CNKI and Google Scholar were performed up to June 15, 2013. Additionally, hand searching of the references of identified articles was performed. Data analyses were carried out by Stata 11.0.</p> </sec> <sec id="ss3"> <title>Results:</title> <p>Seven studies were included in the final meta-analysis, covering a total of 1661 T2DM cases and 1265 controls. The results showed evidence for significant association between the NAD(P)H oxidase P22 phox gene C242T polymorphism and T2DM risk (for T/T vs. T/C: OR = 1.61, 95% CI = 1.14–2.26, <italic>p</italic> = 0.007; for T/T vs. T/C + C/C: OR = 1.50, 95% CI = 1.10–2.05, <italic>p</italic> = 0.009). In the subgroup analysis, there was also evidence for significant association between the NAD(P)H oxidase P22 phox gene C242T polymorphism and T2DM risk, either for Asians (T/T vs. T/C + C/C: OR = 1.74, 95% CI = 1.15–2.64, <italic>p</italic> = 0.009) or for non-Asians (for T allele vs C allele: OR = 1.30, 95% CI = 1.04–1.61, <italic>p</italic> = 0.02).</p> </sec> <sec id="ss4"> <title>Conclusions:</title> <p>The present meta-analysis indicates that the NAD(P)H oxidase P22 phox gene 242 T allele might be associated with an increased T2DM risk.</p> </sec> </abstract>