Presence of cytomegalovirus DNA in leucocytes is associated with increased oxidative stress and subclinical atherosclerosis in healthy adults. (March 2014)

• Record Type: Journal Article
• Authors: Lee, Yu-Lin; Liu, Chun-Eng; Cho, Wen-Long; Kuo, Chen-Ling; Cheng, Wen-Ling; Huang, Ching-Shan; Liu, Chin-San
• Is Part Of: Biomarkers. Volume 19:Number 2(2014)
• Page Start: 109
• Page End: 113
• Publication Date: 2014-03
• Subjects: Biochemical markers -- Periodicals; 610.28
• DOI: 10.3109/1354750X.2013.877967
• Languages: English
• ISSNs: 1354-750X

Abstract

<abstract> <title>Abstract</title> <p> <italic>Objective</italic>: Investigate the latent cytomegalovirus (CMV) infection as a biomarker of oxidative stress and atherosclerosis.</p> <p> <italic>Methods</italic>: Latent CMV infection was diagnosed in healthy individuals with PCR-evidence of CMV DNA in peripheral leucocytes. Oxidative stress and atherosclerosis were measured by mitochondrial DNA oxidative damage index (mtDNA^ΔCT) and intima media thickness (IMT).</p> <p> <italic>Results</italic>: The CMV DNA positive subjects had a higher mean mtDNA^ΔCT and greater IMT than subjects in the control group.</p> <p> <italic>Conclusions</italic>: Presence of CMV DNA in leucocytes, as a marker of latent CMV infection, was associated with increased levels of oxidative stress and subclinical atherosclerosis in healthy adults.</p> </abstract>