Biomarkers as outcome predictors in subarachnoid hemorrhage – a systematic review. (March 2014)

• Record Type: Journal Article
• Authors: Hong, Caron M.; Tosun, Cigdem; Kurland, David B.; Gerzanich, Volodymyr; Schreibman, David; Simard, J. Marc
• Is Part Of: Biomarkers. Volume 19:Number 2(2014)
• Page Start: 95
• Page End: 108
• Publication Date: 2014-03
• Subjects: Biochemical markers -- Periodicals; 610.28
• DOI: 10.3109/1354750X.2014.881418
• Languages: English
• ISSNs: 1354-750X

Abstract

<abstract> <title>Abstract</title> <p> <italic>Context</italic>: Subarachnoid hemorrhage (SAH) has a high fatality rate and many suffer from delayed neurological deficits. Biomarkers may aid in the identification of high-risk patients, guide treatment/management and improve outcome.</p> <p> <italic>Objective</italic>: The aim of this review was to summarize biomarkers of SAH associated with outcome.</p> <p> <italic>Methods</italic>: An electronic database query was completed, including an additional review of reference lists to include all potential human studies.</p> <p> <italic>Results</italic>: A total of 298 articles were identified; 112 were reviewed; 55 studies were included.</p> <p> <italic>Conclusion</italic>: This review details biomarkers of SAH that correlate with outcome. It provides the basis for research investigating their possible translation into the management of SAH patients.</p> </abstract>