Articular Cartilage Tissue Engineering: Development and Future: A Review. Issue 1 (March 2014)

• Record Type: Journal Article
• Authors: Wang (Jack), Zimin; Peng, Jiang
• Is Part Of: Journal of musculoskeletal pain. Volume 22:Issue 1(2014)
• Page Start: 68
• Page End: 77
• Publication Date: 2014-03
• Subjects: Nonarticular rheumatism -- Periodicals; Myalgia -- Periodicals; Pain -- Periodicals; Musculoskeletal system -- Diseases -- Periodicals; 616.7
• DOI: 10.3109/10582452.2014.883017
• Languages: English
• ISSNs: 1058-2452

Abstract

<abstract> <title>Abstract</title> <p> <bold>Background</bold>: Articular cartilage is an avascular structure. Injured cartilage cannot self-repair, which results in joint pain and loss of mobility, eventually requiring articular cartilage replacement. Cartilage tissue engineering is a promising approach for regeneration and repair.</p> <p> <bold>Findings</bold>: In this paper, we reviewdc the normal structure and function of articular cartilage, the history of clinical techniques of cartilage tissue engineering, and two categories of cell sources for cartilage engineering. We also explored the environment of cell regeneration that includes scaffolds, growth factors, biomechanical stimulation in a three-dimensional bioreactor, and possible mechanical signal pathways.</p> <p> <bold>Conclusion</bold>: Successful cartilage tissue engineering relies on "energetic" cells, a number of growth factors, reliable scaffolds such as articular cartilage extracellular matrix oriented scaffolds, and joint-like mechanical stimuli.</p> </abstract>