Variability of oxidative stress biomarkers in hemodialysis patients. (March 2014)

• Record Type: Journal Article
• Authors: Dahwa, Rumbidzai; Fassett, Robert G.; Wang, Zaimin; Briskey, David; Mallard, Alistair R.; Coombes, Jeff S.
• Is Part Of: Biomarkers. Volume 19:Number 2(2014)
• Page Start: 154
• Page End: 158
• Publication Date: 2014-03
• Subjects: Biochemical markers -- Periodicals; 610.28
• DOI: 10.3109/1354750X.2013.867533
• Languages: English
• ISSNs: 1354-750X

Abstract

<abstract> <title>Abstract</title> <p>Oxidative stress biomarkers may have a role in the future to assist clinical decisions regarding the use of antioxidant therapies and their efficacy. The aims of this study were to evaluate the within and between-individual variability of plasma oxidative stress biomarkers and investigate factors affecting their variability. Plasma F2-isoprostanes and protein carbonyls were measured in 14 hemodialysis patients every 2 weeks for 10 weeks. Within-individual coefficients of variation (CVs) were isoprostanes = 30.4% (range = 6.1–66.7%) and protein carbonyls = 16.3% (8.4–29.5%). Between-individual CVs were isoprostanes = 34.4% (28.9–40.2%) and protein carbonyls = 19.5% (15.6–24.5%). There were no significant (<italic>p</italic> &gt; 0.05) relationships between the oxidative stress biomarkers and dietary antioxidant intake, medications, clinical and demographic parameters.</p> </abstract>