Association of Helicobacter pylori infection with chemotherapy-induced thrombocytopenia in patients with stage III colon cancer: A pilot study†. (March 2014)

• Record Type: Journal Article
• Authors: Tanriverdi, Ozgur
• Is Part Of: Platelets. Volume 25:Number 2(2014:Mar.)
• Page Start: 118
• Page End: 124
• Publication Date: 2014-03
• Subjects: Blood platelets -- Periodicals; Blood Platelets -- Periodicals; 615.39
• DOI: 10.3109/09537104.2013.778397
• Languages: English
• ISSNs: 0953-7104

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p>In this study, the effects of the pre-treatment presence of <italic>Helicobacter pylori</italic> (<italic>H. pylori</italic>) infection on chemotherapy-induced thrombocytopenia (CIT) were investigated in patients with stage III colon cancer (CC). A cohort of 74 patients with early stage CC was analysed through a review of clinical records and personal interviews. <italic>Helicobacter pylori</italic> infections were diagnosed in these patients prior to chemotherapy. The subjects were divided into two groups according to <italic>H. pylori</italic> infection status: Group 1, <italic>H. pylori</italic>-positive and Group 2, <italic>H. pylori</italic>-negative. In all patients, bone marrow toxicity and other study variables were compared. <italic>Helicobacter pylori</italic> infections were detected in 31 of the74 CC patients. <italic>Helicobacter pylori-infected</italic> patients (Group 1) showed significantly higher incidences of CIT than did non-infected patients (Group 2; <italic>p</italic> = 0.029). <italic>Helicobacter pylori</italic> infection status correlated significantly with tumour location (<italic>r</italic> = 0.547; <italic>p</italic> = 0.043) and the most common location of CC in <italic>H. pylori-</italic>infected patients was the ascending colon (<italic>n</italic> = 13, 42%) in comparison to non-infected patients (<italic>n</italic> = 6, 14%; <italic>p</italic> = 0.042). The relationship between CIT and <italic>H. pylori</italic> infection status in CC was determined to be independent from the other study variables (<italic>p</italic> = 0.037; OR = 3.32, CI 95% = 1.16–9.70). In this study, the small number of patients resulted in an inadequate demonstration of the relationship between <italic>H. pylori</italic> infection and CIT. Therefore, clinical and molecular studies that include more patients are warranted.</p> </abstract>