Predisposing factors for recurrence of HBV-related small hepatocellular carcinoma after percutaneous radiofrequency ablation. (March 2014)

• Record Type: Journal Article
• Authors: Sohn, Won; Paik, Yong-Han; Lee, Min Woo; Rhim, Hyunchul; Lim, Hyo Keun; Cho, Ju Yeon; Gwak, Geum-Youn; Choi, Moon Seok; Lee, Joon Hyeok; Koh, Kwang Cheol; Paik, Seung Woon; Yoo, Byung Chul
• Is Part Of: Scandinavian journal of gastroenterology. Volume 49:Number 3(2014)
• Page Start: 373
• Page End: 380
• Publication Date: 2014-03
• Subjects: Gastroenterology -- Periodicals; Digestive organs -- Diseases -- Periodicals; 616.33
• DOI: 10.3109/00365521.2013.871745
• Languages: English
• ISSNs: 0036-5521

Abstract

<abstract> <title>Abstract</title> <p> <bold> <italic>Background.</italic> </bold> Radiofrequency ablation (RFA) as a curative therapy for hepatocellular carcinoma (HCC) is widely used. The aim of this study was to investigate predisposing factors for HCC recurrence in patients with hepatitis B virus (HBV)-related small HCC after RFA. <bold><italic>Methods.</italic></bold> A total of 170 patients underwent percutaneous RFA for HBV-related small HCC (≤3 cm in diameter) from January 2008 to December 2010 at Samsung Medical Center. We analyzed the risk factors for recurrence of HCC after RFA. <bold><italic>Results.</italic></bold> The median follow-up duration was 27.0 months. A total of 89 patients (52%) experienced recurrence after percutaneous RFA. Cumulative recurrence-free rates after RFA at 1-, 3-, and 5 years were 81.3%, 47.2% and 35.7%, respectively. Univariate analysis showed that predisposing factors for HCC recurrence were the multinodularity (hazard ratio (HR) 2.22, <italic>p</italic> = 0.005), pre-RFA HBV DNA levels ≥2000 IU/mL (HR 1.61, <italic>p</italic> = 0.025), and Barcelona Clinic Liver Cancer stage A (HR 1.54, <italic>p</italic> = 0.046). The independent risk factors for recurrence by multivariate analysis were the multinodularity (HR 1.94, <italic>p</italic> = 0.026) and pre-RFA HBV DNA levels ≥2000 IU/mL (HR 1.57, <italic>p</italic> = 0.039). <bold><italic>Conclusion.</italic></bold> Multinodularity and HBV DNA levels were associated with the recurrence of HBV-related small HCC after RFA.</p> </abstract>