Haemodynamic effects, safety, and pharmacokinetics of human stresscopin in heart failure with reduced ejection fraction†. (June 2013)

• Record Type: Journal Article
• Authors: Gheorghiade, Mihai; Greene, Stephen J.; Ponikowski, Piotr; Maggioni, Aldo P.; Korewicki, Jerzy; Macarie, Cezar; Metra, Marco; Grzybowski, Jacek; Bubenek‐Turconi, Serban‐Ion; Radziszewski, Waldemar; Olson, Allan; Bueno, Orlando F.; Ghosh, Atalanta; Deckelbaum, Lawrence I.; Li, Lilian Y.; Patel, Ayan R.; Koester, Andreas; Konstam, Marvin A.
• Is Part Of: European journal of heart failure. Volume 15:Number 6(2013)
• Page Start: 679
• Page End: 689
• Publication Date: 2013-06
• Subjects: Heart failure -- Periodicals; Heart Failure -- Periodicals; Insuffisance cardiaque -- Périodiques; Heart failure; Periodicals; 616.129005
• DOI: 10.1093/eurjhf/hft023
• Languages: English
• ISSNs: 1388-9842

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="ejhfhft023-sec-0001" sec-type="section"> <title>Aims</title> <p>Human stresscopin is a corticotropin‐releasing factor (CRF) type 2 receptor (CRFR<sub>2</sub>) selective agonist and a member of the CRF peptide family. Stimulation of CRFR<sub>2</sub> improves cardiac output and left ventricular ejection fraction (LVEF) in patients with stable heart failure (HF) with reduced LVEF. We examined the safety, pharmacokinetics, and effects on haemodynamics and serum biomarkers of intravenous human stresscopin acetate (JNJ‐9588146) in patients with stable HF with LVEF ≤35% and cardiac index (CI) ≤2.5 L/min/m<sup>2</sup>.</p> </sec> <sec id="ejhfhft023-sec-0002" sec-type="section"> <title>Methods and results</title> <p>Sixty‐two patients with HF and LVEF ≤35% were instrumented with a pulmonary artery catheter and randomly assigned (ratio 3:1) to receive an intravenous infusion of JNJ‐9588146 or placebo. The main study was an ascending dose study of three doses (5, 15, and 30 ng/kg/min) of study drug or placebo administered in sequential 1 h intervals (3 h total). Statistically significant increases in CI and reduction in systemic vascular resistance (SVR) were observed with both the 15 ng/kg/min (2 h time point) and 30 ng/kg/min (3 h time point) doses of JNJ‐9588146 without significant changes in heart rate (HR) or systolic blood pressure (SBP). No statistically significant reductions in pulmonary capillary wedge pressure (PCWP) were seen with any dose tested in the primary analysis, although a trend towards reduction was seen.</p> </sec> <sec id="ejhfhft023-sec-0003" sec-type="section"> <title>Conclusion</title> <p>In HF patients with reduced LVEF and CI, ascending doses of JNJ‐9588146 were associated with progressive increases in CI and reductions in SVR without significant effects on PCWP, HR, or SBP.</p> <p> <bold>Trial registration</bold>: NCT01120210</p> </sec> </abstract>