Comparison of outcomes of twins conceived spontaneously and by artificial reproductive therapy. (March 2014)

• Record Type: Journal Article
• Authors: Anbazhagan, Akila; Hunter, Alyson; Breathnach, Fionnuala M.; Mcauliffe, Fionnuala M.; Geary, Michael P.; Daly, Sean; Higgins, John R.; Morrison, John J.; Burke, Gerard; Higgins, Shane; Dicker, Patrick; Tully, Elizabeth; Carroll, Stephen; Malone, Fergal D.
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 27:Number 5(2014:May)
• Page Start: 458
• Page End: 462
• Publication Date: 2014-03
• Subjects: Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• DOI: 10.3109/14767058.2013.818653
• Languages: English
• ISSNs: 1476-7058

Abstract

<abstract> <title>Abstract</title> <p> <italic>Objective</italic>: To compare the outcomes of twin pregnancies conceived by artificial reproductive techniques (ART) with those of spontaneous conception.</p> <p> <italic>Study design</italic>: In this multicenter prospective trial, comparisons were made between methods of conception in twin pregnancies, for maternal and perinatal outcomes.</p> <p> <italic>Results</italic>: Of 1001 twin pairs, 763/1001 (72.7%) were spontaneously conceived and 238/1001(27.3%) were conceived by ART. There were no significant differences between the two groups with respect to obstetric complications. There were 13 per 1000 (20/1504; 1%) perinatal deaths in the spontaneously conceived group and 6 per 1000 (3/466; 0.6%) in the ART group (<italic>p</italic> = 0.8141). We found no differences in gestational age at delivery (median 36.9 versus 37.0 weeks), birth weight (median 2520 g versus 2538 g), or in a composite measure of adverse perinatal outcome (17% versus 15%) between the groups.</p> <p> <italic>Conclusion</italic>: There were no differences in the rate of adverse obstetric or perinatal outcomes between twins conceived naturally compared with twins conceived by assisted conception.</p> </abstract>