Interleukin receptor family member ST2 concentrations in patients following heart transplantation. (May 2013)

• Record Type: Journal Article
• Authors: Januzzi, James L.; Horne, Benjamin D.; Moore, Stephanie A.; Galenko, Oxana; Snow, Gregory L.; Brunisholz, Kimberly D.; Muhlestein, Joseph B.; Alharethi, Rami; Carlquist, John F.; Budge, Deborah; Rasmussen, Kismet; Kfoury, Abdallah G.
• Is Part Of: Biomarkers. Volume 18:Number 3(2013)
• Page Start: 250
• Page End: 256
• Publication Date: 2013-05
• Subjects: Biochemical markers -- Periodicals; 610.28
• DOI: 10.3109/1354750X.2013.773081
• Languages: English
• ISSNs: 1354-750X

Abstract

<abstract> <title>Abstract</title> <p> <italic>Objective</italic>: To evaluate soluble (s) ST2 as a biomarker of rejection, allograft vasculopathy and mortality after orthotopic heart transplantation (OHT).</p> <p> <italic>Methods</italic>: sST2 concentrations were measured in 241 patients following OHT.</p> <p> <italic>Results</italic>: Elevated sST2 was associated with cellular rejection (CR) ≥1R, with highest rates of CR in the 4th sST2 quartile (<italic>p</italic> = 0.003). No significant association between sST2 and antibody-mediated rejection or allograft vasculopathy was found. sST2 ≥30 ng/mL independently predicted death over 7-year follow-up (HR = 2.01; 95% CI 1.15–3.51; <italic>p</italic> = 0.01).</p> <p> <italic>Conclusion</italic>: Concentrations of sST2 are associated with the presence of CR and predict long-term mortality following OHT.</p> </abstract>