Association analysis between MDR1 gene polymorphisms and risk of hepatocellular carcinoma in Chinese population. (May 2013)

• Record Type: Journal Article
• Authors: Yang, Daokun; Zhou, Fujun; Wang, Xinwei; Gao, Haili; Li, Guangyan; Xue, Minghui
• Is Part Of: Biomarkers. Volume 18:Number 3(2013)
• Page Start: 236
• Page End: 241
• Publication Date: 2013-05
• Subjects: Biochemical markers -- Periodicals; 610.28
• DOI: 10.3109/1354750X.2013.773079
• Languages: English
• ISSNs: 1354-750X

Abstract

<abstract> <title>Abstract</title> <p>The objective of this study was to evaluate the association between <italic>MDR1</italic> gene polymorphisms and hepatocellular carcinoma (HCC) risk. Genomic DNA of 1431 subjects was extracted from peripheral blood and genotyping was performed using the created restriction site-polymerase chain reaction (CRS-PCR). We found that the c.1465C &gt; T single nucleotide polymorphisms (SNP) increased HCC risk in all genetic models (<italic>p</italic> &lt; 0.05) and the allele-T of c.1465C &gt; T may contribute to the risk of HCC. No significantly increased HCC risk was detected in c.159G &gt; T SNP. Our data indicated that the genetic variants of <italic>MDR1</italic> gene may be a valuable molecular marker for HCC.</p> </abstract>