VKORC1 C1173T and VKORC1 G-1639A Gene Polymorphisms in Turkish Behçet's Patients with Ocular and Non-ocular Involvement. (March 2014)

• Record Type: Journal Article
• Authors: Demir, Helin Deniz; Ortak, Hüseyin; Şahin, Şemsettin; Ateş, Ömer; Benli, İsmail; İnanır, Ahmet
• Is Part Of: Ophthalmic genetics. Volume 35:Number 1(2014:Mar.)
• Page Start: 7
• Page End: 11
• Publication Date: 2014-03
• Subjects: Eye -- Diseases -- Genetic aspects -- Periodicals; Eye Diseases -- genetics -- Periodicals; Eye Diseases -- in infancy & childhood -- Periodicals; 617.7
• DOI: 10.3109/13816810.2013.763994
• Languages: English
• ISSNs: 1381-6810

Abstract

<abstract> <title>Abstract</title> <p> <italic>Background:</italic> Behçet's disease (BD) is a multisystemic vasculitis with unknown etiology. Vitamin K epoxide reductase complex subunit 1 (<italic>VKORC1</italic>) is the key enyzme in the formation of active vitamin K that is a cofactor of various coagulation factors. Polymorphisms of the <italic>VKORC1</italic> may affect the levels of active forms of vitamin K-dependent coagulation proteins and the tendency to thrombosis. The current study aimed to evaluate the role of <italic>VKORC1</italic> gene polymorphisims in ocular and non-ocular Behçet's disease.</p> <p> <italic>Methods: VKORC1 C1173T</italic> (rs 9934438) and <italic>G-1639A</italic> (rs 9923231) gene polymorphisms were evaluated by real-time polymerase chain reaction-based DNA analysis. The frequency of alleles and distribution of genotypes were assessed by the chi-squared test. Genotype distribution and Hardy–Weinberg equilibrium were tested with the χ<sup>2</sup> test for quality of fit.</p> <p> <italic>Results:</italic> The distribution of GG, GA and AA and CC, CT, TT genotypes and the frequency of G, A and C, T alleles were not found to be different between patients and controls (<italic>p</italic> = 0.5651; <italic>p</italic> = 0.335 respectively), as well as patients with or without eye involvement (<italic>p</italic> = 0.9267; <italic>p</italic> = 0.384 respectively).</p> <p> <italic>Conclusion: VKORC1</italic> polymorphisms seem not to be related with the thrombotic state of systemic and ocular Behçet's disease.</p> </abstract>