Deep brain stimulation lead-contact heating during 3T MRI: single- versus dual-channel pulse generator configurations. (1st March 2014)

• Record Type: Journal Article
• Authors: Nazzaro, Jules M.; Klemp, Joshua A.; Brooks, William M.; Cook-Wiens, Galen; Mayo, Matthew S.; Van Acker III, Gustaf M.; Lyons, Kelly E.; Cheney, Paul D.
• Is Part Of: International journal of neuroscience. Volume 124:Number 3(2014:Mar.)
• Page Start: 166
• Page End: 174
• Publication Date: 2014-03-01
• Subjects: Nervous system -- Periodicals; 612.805
• DOI: 10.3109/00207454.2013.840303
• Languages: English
• ISSNs: 0020-7454

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p> <italic>Background</italic>: Magnetic resonance imaging (MRI) after deep brain stimulation (DBS) carries the risk of heating at the lead-contacts within the brain. <italic>Objective/Hypothesis</italic>: To compare the effect of single- and dual-channel DBS implantable pulse generator (IPG) configurations on brain lead-contact heating during 3T MRI. <italic>Methods</italic>: A phantom with bilateral brain leads and extensions connected to two single-channel IPGs or a dual-channel right or left IPG was utilized. Using a transmit/receive head coil, seven scan sequences were conducted yielding a range of head-specific absorption rates (SAR-H). Temperature changes (ΔT) at the bilateral 0 and 3 lead-contacts were recorded, and normalized temperatures (ΔT/SAR-H) and slopes defining the ΔT/SAR-H over the SAR-H range were compared. <italic>Results</italic>: Greater heating was strongly correlated with higher SAR-H in all configurations. For each scan sequence, the ΔT/SAR-H of single-channel left lead-contacts was significantly greater than the ΔT/SAR-H of either dual-channel configuration. The slope defining the relationship between ΔT and SAR-H for the single-channel left lead (1.68°C/SAR-H) was significantly greater (<italic>p</italic> < 0.0001) than the ΔT/SAR-H slope for the single-channel right lead (0.97°C/SAR-H), both of which were significantly greater (<italic>p</italic> < 0.0001) than the ΔT/SAR-H slopes of left or right leads (range 0.68 to 0.70°C/SAR-H) in the dual-channel configurations. There were no significant differences in ΔT/SAR-H slope values between the dual-channel configurations. <italic>Conclusion</italic>: DBS hardware configuration using bilateral single-channel versus unilateral dual-channel IPGs significantly affects DBS lead-contact heating during 3T MRI brain scanning.</p> </abstract>