Marginal zone lymphomas with monocytoid morphology express T-bet and are associated with a low number of T cells in extranodal locations. Issue 1 (January 2014)

• Record Type: Journal Article
• Authors: Lohneis, Philipp; Wienert, Stephan; Klauschen, Frederick; Ullrich, Andrea; Anagnostopoulos, Ioannis; Jöhrens, Korinna
• Is Part Of: Leukemia & lymphoma. Volume 55:Issue 1(2014:Jan.)
• Page Start: 143
• Page End: 148
• Publication Date: 2014-01
• Subjects: Leukemia -- Periodicals; Lymphomas -- Periodicals; 616.99419
• DOI: 10.3109/10428194.2013.797082
• Languages: English
• ISSNs: 1042-8194

Abstract

<abstract> <title>Abstract</title> <p>The presence of tumor cells with monocytoid morphology in marginal zone lymphoma (MZL) has been described previously. Reactive monocytoid B cells bear a distinct immunophenotype and typically express T-bet, which clearly distinguishes them from nodal marginal zone B cells. The latter are positive for CD27 and negative for T-bet. We analyzed 74 MZLs for the expression of T-bet and correlated these results with the presence of monocytoid morphology. Expression of T-bet correlated with the presence of monocytoid morphology in MZLs. In analogy to reactive monocytoid B lymphocytes, we also found a significantly lower relative amount of intratumoral T lymphocytes in extranodal MZL with monocytoid morphology.</p> </abstract>