Proportionate Reduction in Uncertainty of Late Onset Infection in Pre-term Infants by Neutrophil CD64 Measurement. (1st February 2014)

• Record Type: Journal Article
• Authors: Berrington, Janet Elizabeth; Hearn, Richard Iain; Hall, Chris; Stewart, Christopher James; Cummings, Stephen Paul; Embleton, Nicholas David
• Is Part Of: Fetal and pediatric pathology. Volume 33:Number 1(2014)
• Page Start: 16
• Page End: 22
• Publication Date: 2014-02-01
• Subjects: Pathology, Molecular -- Periodicals; Pediatrics -- Periodicals; Molecular biology -- Periodicals; Pediatric pathology -- Periodicals; Fetal Diseases -- pathology -- Periodicals; Infant, Newborn, Diseases -- pathology -- Periodicals; Pediatrics -- Periodicals; 618.92007
• DOI: 10.3109/15513815.2013.842270
• Languages: English
• ISSNs: 1551-3815

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p> <italic>Objective</italic>: Establish how neutrophil CD64 performs as a marker of definite infection in pre-term infants in comparison to C reactive protein (CRP) and procalcitonin (PCT). <italic>Methods</italic>: A total of 38 pre-term infants with suspected late onset infection had CD64 measured by flow cytometry. Proportionate reduction in uncertainty (PRU) curves were generated for CD64 counts at various threshold values. <italic>Results</italic>: PRU curves reduced the residual uncertainty of the presence of infection by up to 64%. <italic>Conclusions</italic>: The CD64 appears to be a useful point of care test (POCT) for further defining the likelihood of infection and performs better than CRP or PCT at helping to rule in infection.</p> </abstract>