Allergic bronchopulmonary mycosis due to fungi other than Aspergillus: a global overview. (February 2014)

• Record Type: Journal Article
• Authors: Chowdhary, Anuradha; Agarwal, Kshitij; Kathuria, Shallu; Gaur, Shailendra Nath; Randhawa, Harbans Singh; Meis, Jacques F.
• Is Part Of: Critical reviews in microbiology. Volume 40:Number 1(2014:Feb.)
• Page Start: 30
• Page End: 48
• Publication Date: 2014-02
• Subjects: Microbiology -- Periodicals; Microbiology -- Periodicals; Review Literature -- Periodicals; 579
• DOI: 10.3109/1040841X.2012.754401
• Languages: English
• ISSNs: 1040-841X

Abstract

<abstract> <title>Abstract</title> <p>Allergic bronchopulmonary mycosis (ABPM) is a hypersensitivity-mediated disease of worldwide distribution. We reviewed 143 reported global cases of ABPM due to fungi other than aspergilli. The commonest etiologic agent was <italic>Candida albicans</italic>, reported in 60% of the cases, followed by <italic>Bipolaris</italic> species (13%), <italic>Schizophyllum commune</italic> (11%), <italic>Curvularia</italic> species (8%), <italic>Pseudallescheria boydii</italic> species complex (3%) and rarely, <italic>Alternaria alternata, Fusarium vasinfectum, Penicillium</italic> species, <italic>Cladosporium cladosporioides, Stemphylium languinosum, Rhizopus oryzae, C. glabrata, Saccharomyces cerevisiae</italic> and <italic>Trichosporon beigelii</italic>. India accounted for about 47% of the globally reported cases of ABPM, attributed predominantly to <italic>C. albicans</italic>, followed by Japan (16%) where <italic>S. commune</italic> predominates, and the remaining one-third from the USA, Australia and Europe. Notably, bronchial asthma was present in only 32% of ABPM cases whereas its association with development of allergic bronchopulmonary aspergillosis (ABPA) is known to be much more frequent. The cases reviewed herein revealed a median IgE value threefold higher than that of ABPA, suggesting that the etiologic agents of ABPM incite a stronger immunological response than that by aspergilli in ABPA. ABPM is currently underdiagnosed, warranting comprehensive basic and clinical studies in order to elucidate its epidemiology and to devise a more effective therapy.</p> </abstract>