Isolation, pharmacological activity and structure determination of physalin B and 5β, 6β‐epoxyphysalin B isolated from Congolese Physalis angulata L. (15th December 2013)

• Record Type: Journal Article
• Authors: Mangwala Kimpende, Peter; Lusakibanza, Mariano; Mesia, Kahunu; Tona, Lutete; Tits, Monique; Angenot, Luc; Frédérich, Michel; Van Meervelt, Luc
• Is Part Of: Acta crystallographica. Volume 69:Part 12(2013:Dec.)
• Page Start: 1557
• Page End: 1562
• Publication Date: 2013-12-15
• Subjects: Crystallography -- Periodicals; Crystals -- Periodicals; 548.05
• DOI: 10.1107/S010827011303117X
• Languages: English
• ISSNs: 0108-2701

Abstract

<abstract abstract-type="main" xml:lang="en"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <italic>Physalis angulata</italic> L., an annual herb from the Solanaceae family, is widely used in popular medicine in tropical countries to treat a variety of diseases. Two products, (<bold>X</bold>) and (<bold>Y</bold>), were isolated from a crude CH₂Cl₂ extract of dried Congolese <italic>Physalis angulata</italic> L. plants and crystallized from acetone for structure elucidation. Compound (<bold>X</bold>) corresponds to a physalin B dimer acetone solvate hydrate (2C₂₈H₃₀O₉·C₃H₆O·0.22H₂O), while compound (<bold>Y</bold>) crystallizes as a mixed crystal containing two physalin B molecules which overlap with 5β, 6β‐epoxyphysalin B, also known as physalin F, and one acetone molecule in the asymmetric unit (1.332C₂₈H₃₀O₉·0.668C₂₈H₃₀O₁₀·C₃H₆O). Antiplasmodial activity, cytotoxic activity and selectivity indices were determined for crude extracts and the two isolated products (<bold>X</bold>) and (<bold>Y</bold>).</p> </abstract>