Associations of leukocyte telomere length with body anthropometric indices and weight change in chinese women. (29th May 2013)

• Record Type: Journal Article
• Authors: Cui, Yong; Gao, Yu‐Tang; Cai, Qiuyin; Qu, Shimian; Cai, Hui; Li, Hong‐Lan; Wu, Jie; Ji, Bu‐Tian; Yang, Gong; Chow, Wong‐Ho; Shu, Xiao‐Ou; Zheng, Wei
• Is Part Of: Obesity. Volume 21:Number 12(2013:Dec.)
• Page Start: 2582
• Page End: 2588
• Publication Date: 2013-05-29
• Subjects: Obesity -- Periodicals; 616.398005
• DOI: 10.1002/oby.20321
• Languages: English
• ISSNs: 1930-7381

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>Objective:</bold> This study evaluated associations of telomere length with various anthropometric indices of general and abdominal obesity, as well as weight change.</p> <p> <bold>Design and Methods:</bold> The study included 2, 912 Chinese women aged 40‐70 years. Monochrome multiplex quantitative polymerase chain reaction was applied to measure relative telomere length.</p> <p> <bold>Results:</bold> Telomere length was inversely associated with body mass index (BMI), waist circumference, waist‐to‐height ratio, weight, and hip circumference (<italic>P</italic><sub>trend</sub> = 0.005, 0.004, 0.004, 0.010, and 0.026, respectively), but not waist‐to‐hip ratio (<italic>P</italic><sub>trend</sub> = 0.116) or height (<italic>P</italic><sub>trend</sub> = 0.675). Weight change since age 50 was further evaluated among women over age 55. Women who maintained their weight within ±5% since age 50, particularly within a normal range (BMI = 18.5‐24.9 kg/m<sup>2</sup>), or reduced their weight from overweight (BMI = 25‐29.9 kg/m<sup>2</sup>) or obesity (BMI ≥30 kg/m<sup>2</sup>) to normal range, had a longer mean of current telomere length than women who gained weight since age 50 (<italic>P</italic><sub>trend</sub> = 0.025), particularly those who stayed in obesity or gained weight from normal range or overweight to obesity (<italic>P</italic> = 0.023).</p> <p> <bold>Conclusion:</bold> Our findings show that telomere shortening is associated with obesity and that maintaining body weight within a normal range helps maintain telomere length.</p> </abstract>