Effects of sugar‐sweetened beverages on plasma acylation stimulating protein, leptin and adiponectin: Relationships with Metabolic Outcomes. (13th June 2013)

• Record Type: Journal Article
• Authors: Rezvani, Reza; Cianflone, Katherine; McGahan, John P.; Berglund, Lars; Bremer, Andrew A.; Keim, Nancy L.; Griffen, Steven C.; Havel, Peter J.; Stanhope, Kimber L.
• Is Part Of: Obesity. Volume 21:Number 12(2013:Dec.)
• Page Start: 2471
• Page End: 2480
• Publication Date: 2013-06-13
• Subjects: Obesity -- Periodicals; 616.398005
• DOI: 10.1002/oby.20437
• Languages: English
• ISSNs: 1930-7381

Abstract

<abstract abstract-type="main"> <title> <x xml:space="preserve">Abstract</x> </title> <sec id="oby20437-sec-0001" sec-type="section"> <title>Objective</title> <p>The effects of fructose and glucose consumption on plasma acylation stimulating protein (ASP), adiponectin, and leptin concentrations relative to energy intake, body weight, adiposity, circulating triglycerides, and insulin sensitivity were determined.</p> </sec> <sec id="oby20437-sec-0002" sec-type="section"> <title>Design and Methods</title> <p>Thirty two overweight/obese adults consumed glucose‐ or fructose‐sweetened beverages (25% energy requirement) with their <italic>ad libitum</italic> diets for 8 weeks, followed by sweetened beverage consumption for 2 weeks with a standardized, energy‐balanced diet. Plasma variables were measured at baseline, 2, 8, and 10 weeks, and body adiposity and insulin sensitivity at baseline and 10 weeks.</p> </sec> <sec id="oby20437-sec-0003" sec-type="section"> <title>Results</title> <p>Fasting and postprandial ASP concentrations increased at 2 and/or 8 weeks. ASP increases correlated with changes in late‐evening triglyceride concentrations. At 10 weeks, fasting adiponectin levels decreased in both groups, and decreases were inversely associated with baseline intra‐abdominal fat volume. Sugar consumption increased fasting leptin concentrations; increases were associated with body weight changes. The 24‐h leptin profiles increased during glucose consumption and decreased during fructose consumption. These changes correlated with changes of 24‐h insulin levels.</p> </sec> <sec id="oby20437-sec-0004" sec-type="section"> <title>Conclusions</title> <p>The consumption of fructose and glucose beverages induced changes in plasma concentrations of ASP, adiponectin, and leptin. Further study is required to determine if these changes contribute to the metabolic dysfunction observed during fructose consumption.</p> </sec> </abstract>