Effect of mitochondrial, APOE. ACE and NOS3 gene polymorphisms on cardiovascular risk factors among the Vaqueiros de Alzada, a Northern Spain human isolate. (January 2014)

• Record Type: Journal Article
• Authors: Gómez, Pedro; Gómez, Juan; Corao, Ana I.; De Canga, Julio; Coto, Eliecer
• Is Part Of: Annals of human biology. Volume 41:Number 1(2014:Jan./Feb.)
• Page Start: 94
• Page End: 97
• Publication Date: 2014-01
• Subjects: Human biology -- Periodicals; 612
• DOI: 10.3109/03014460.2013.827738
• Languages: English
• ISSNs: 0301-4460

Abstract

<abstract> <title>Abstract</title> <p> <italic>Background</italic>: The <italic>Vaqueiros de Alzada</italic> are a human isolate from Asturias, a Northern Spain region. Several hypotheses have been proposed to explain the origin of <italic>Vaqueiros</italic>.</p> <p> <italic>Methods and results</italic>: To determine whether the <italic>Vaqueiros</italic> and non-<italic>Vaqueiros</italic> from the same region have different genetic backgrounds, this study analysed nine mtDNA polymorphisms that define the common European mitochondrial haplogroups in a cohort of <italic>Vaqueiros</italic> (<italic>n</italic> = 60) and non-<italic>Vaqueiros</italic> (<italic>n</italic> = 110). Haplogroup H was the most frequent in <italic>Vaqueiros</italic> (42%) and non-<italic>Vaqueiros</italic> (46%). A total of 37% <italic>Vaqueiro</italic>s were H1, compared to 31% of the non-<italic>Vaqueiros</italic>. This study also genotyped the two groups for three polymorphisms at the <italic>NOS3. APOE</italic> and <italic>ACE</italic> genes, that have previously been linked to risk of cardiovascular diseases. Allele and genotype frequencies did not differ between <italic>Vaqueiros</italic> and <italic>non-Vaqueiros</italic>. In addition, none of these polymorphisms were related to risk of hypertension, diabetes or hypercholesterolaemia in the two groups.</p> <p> <italic>Conclusion</italic>: The data suggested that <italic>Vaqueiros</italic> share the main haplogroup distribution as their <italic>non-Vaqueiros</italic> neighbours and other Cantabrian populations. In addition, no effect of the mitochondrial, <italic>NOS3. APOE</italic> and <italic>ACE</italic> polymorphisms on cardiovascular risk factors was observed.</p> </abstract>