Atherosclerosis, biomarkers of atherosclerosis and Alzheimer's disease. (1st January 2014)

• Record Type: Journal Article
• Authors: Fiolaki, Aidonio; Tsamis, Konstantinos I.; Milionis, Haralampos J.; Kyritsis, Athanassios P.; Kosmidou, Maria; Giannopoulos, Sotirios
• Is Part Of: International journal of neuroscience. Volume 124:Number 1(2014:Jan.)
• Page Start: 1
• Page End: 11
• Publication Date: 2014-01-01
• Subjects: Nervous system -- Periodicals; 612.805
• DOI: 10.3109/00207454.2013.821988
• Languages: English
• ISSNs: 0020-7454

Abstract

<abstract> <title> <x xml:space="preserve">Abstract</x> </title> <p>Alzheimer's disease (AD) is the most prevalent type of dementia, involving progressive deterioration of neuronal networks. Although the pathophysiological mechanism of AD is not fully elucidated, apart from β-amyloid and tau protein, a diverse number of factors such as cardiovascular risk factors, inflammation, and lipids metabolism may play a significant role. Numerous epidemiological and laboratory studies support vascular injury and inflammation, as key pathological processes. The present review is focused on cardiovascular risk factors, lipids, and circulating biomarkers of inflammation, discussing them as independent mechanisms converging to the same final pathogenetic cascade of AD.</p> </abstract>