Successful treatment with fumagillin of the first pediatric case of digestive microsporidiosis in a liver‐kidney transplant. Issue 6 (23rd October 2013)

• Record Type: Journal Article
• Authors: Desoubeaux, G.; Maakaroun‐Vermesse, Z.; Lier, C.; Bailly, É.; Morio, F.; Labarthe, F.; Bernard, L.; Chandenier, J.
• Is Part Of: Transplant infectious disease. Volume 15:Issue 6(2013)
• Page Start: E250
• Page End: E259
• Publication Date: 2013-10-23
• Subjects: Transplantation of organs, tissues, etc -- Complications -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 617.01
• DOI: 10.1111/tid.12158
• Languages: English
• ISSNs: 1398-2273

Abstract

<abstract abstract-type="main" id="tid12158-abs-0001"> <title>Abstract</title> <p>We report the first successful use, to our knowledge, of fumagillin alone in a pediatric patient to cure intestinal microsporidiosis in a liver‐kidney transplanted child. Detection of <italic>Enterocytozoon bieneusi</italic> in stool became negative from the first post‐therapeutic control, while digestive symptoms disappeared in 4 days. During a 9‐month follow‐up, polymerase chain reaction and direct examinations remained negative for microsporidia in her feces. No major undesirable effects were noted during the anti‐microsporidial therapy.</p> </abstract>