Mucormycosis as a rare cause of severe gastrointestinal bleeding after multivisceral transplantation. Issue 6 (18th September 2013)

• Record Type: Journal Article
• Authors: Irtan, S.; Lamerain, M.; Lesage, F.; Verkarre, V.; Bougnoux, M.‐E.; Lanternier, F.; Zahar, J.R.; Salvi, N.; Talbotec, C.; Lortholary, O.; Lacaille, F.; Chardot, C.
• Is Part Of: Transplant infectious disease. Volume 15:Issue 6(2013)
• Page Start: E235
• Page End: E238
• Publication Date: 2013-09-18
• Subjects: Transplantation of organs, tissues, etc -- Complications -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 617.01
• DOI: 10.1111/tid.12147
• Languages: English
• ISSNs: 1398-2273

Abstract

<abstract abstract-type="main" id="tid12147-abs-0001"> <title>Abstract</title> <p>Mucormycosis, an emerging fungal infection in solid organ transplant patients, is mostly located in rhino‐orbito‐cerebral, pulmonary, and cutaneous areas, or disseminated with poor prognosis. A 4‐year‐old girl with chronic intestinal pseudo‐obstruction syndrome underwent a modified multivisceral transplantation, including half of the stomach, the duodeno‐pancreas, the small bowel, and the right colon. On postoperative day 5, a digestive perforation was suspected. Surgical exploration found a small necrotic area on the native stomach, which was externally drained. The next day, massive gastric bleeding occurred. During the emergency laparotomy, 2 hemorrhagic ulcers were found and resected from the transplanted stomach. Pathology and fungal culture showed mucormycosis caused by <italic>Lichtheimia</italic> (formerly <italic>Absidia</italic>) <italic>ramosa</italic> in both the transplanted and native stomach. High‐dose intravenous liposomal amphotericin B was immediately started. No other site of fungal infection was found. The child recovered, and 3 years after transplantation, is alive and well, off parenteral nutrition. The originality of this case is the very early presentation after transplantation, the unusual site, and the complete recovery after rapid medico‐surgical management. The origin of the fungus and treatment are discussed.</p> </abstract>