Persistent parvovirus B19 infection resulting in red cell aplasia after allogeneic hematopoietic stem cell transplantation. Issue 6 (18th October 2013)

• Record Type: Journal Article
• Authors: Koda, Y.; Mori, T.; Kato, J.; Kohashi, S.; Kikuchi, T.; Mitsuhashi, T.; Murata, M.; Uemura, T.; Handa, M.; Okamoto, S.
• Is Part Of: Transplant infectious disease. Volume 15:Issue 6(2013)
• Page Start: E239
• Page End: E242
• Publication Date: 2013-10-18
• Subjects: Transplantation of organs, tissues, etc -- Complications -- Periodicals; Communicable diseases -- Periodicals; Infection -- Periodicals; 617.01
• DOI: 10.1111/tid.12155
• Languages: English
• ISSNs: 1398-2273

Abstract

<abstract abstract-type="main" id="tid12155-abs-0001"> <title>Abstract</title> <p>Persistent parvovirus B19 (PVB) infection has been reported sporadically in immunocompromised patients including hematopoietic stem cell and solid organ transplant recipients. However, the pathogenesis of persistent infection has yet to be fully elucidated. We report here a patient with multiple myeloma developing red cell aplasia during the hematopoietic recovery after allogeneic hematopoietic stem cell transplantation (HSCT) caused by PVB. The patient had already had PVB viremia before transplantation and remained asymptomatic. The route of PVB transmission was considered to be direct contact with the patient's family member with primary PVB infection 1 month before transplantation. Treatment with intravenous immunoglobulin resulted in prompt resolution of anemia. These findings suggest that monitoring of PVB DNA is recommended for patients undergoing HSCT and having contact with individuals with documented PVB infection, even if they are asymptomatic.</p> </abstract>