Simulation of oxygen transfer in stented arteries and correlation with in‐stent restenosis. (29th August 2013)

• Record Type: Journal Article
• Authors: Caputo, M.; Chiastra, C.; Cianciolo, C.; Cutrì, E.; Dubini, G.; Gunn, J.; Keller, B.; Migliavacca, F.; Zunino, P.
• Is Part Of: International journal for numerical methods in biomedical engineering. Volume 29:Number 12(2013:Dec.)
• Page Start: 1373
• Page End: 1387
• Publication Date: 2013-08-29
• Subjects: Biomedical engineering -- Periodicals; Imaging systems in medicine -- Periodicals; Numerical analysis -- Periodicals; Engineering mathematics -- Periodicals; 610.28
• DOI: 10.1002/cnm.2588
• Languages: English
• ISSNs: 2040-7939

Abstract

<abstract abstract-type="main" id="cnm2588-abs-0001"> <title>SUMMARY</title> <p id="cnm2588-para-0001">Computational models are used to study the combined effect of biomechanical and biochemical factors on coronary in‐stent restenosis, which is a postoperative remodeling and regrowth pathology of the stented arteries. More precisely, we address numerical simulations, on the basis of Navier–Stokes and mass transport equations, to study the role of perturbed wall shear stresses and reduced oxygen concentration in a geometrical model reconstructed from a real porcine artery treated with a stent. Joining <italic>in vivo</italic> and <italic>in silico</italic> tools of investigation has multiple benefits in this case. On one hand, the geometry of the arterial wall and of the stent closely correspond to a real implanted configuration. On the other hand, the inspection of histological tissue samples informs us on the location and intensity of in‐stent restenosis. As a result, we are able to correlate geometrical factors, such as the axial variation of the artery diameter and its curvature; the numerical quantification of biochemical stimuli, such as wall shear stresses; and the availability of oxygen to the inner layers of the artery, with the appearance of in‐stent restenosis. This study shows that the perturbation of the vessel curvature could induce hemodynamic conditions that stimulate undesired arterial remodeling. Copyright © 2013 John Wiley &amp; Sons, Ltd.</p> </abstract>