Incidence and long‐term outcomes of squamous cell bladder cancer after deceased donor renal transplantation. (11th October 2013)

• Record Type: Journal Article
• Authors: Davis, N. F.; McLoughlin, L. C.; Dowling, C.; Power, R.; Mohan, P.; Hickey, D.; Smyth, G.; Eng, M.; Little, D. M.
• Is Part Of: Clinical transplantation. Volume 27:Number 6(2013:Nov./Dec.)
• Page Start: E665
• Page End: E668
• Publication Date: 2013-10-11
• Subjects: Transplantation of organs, tissues, etc -- Periodicals; 617.95
• DOI: 10.1111/ctr.12245
• Languages: English
• ISSNs: 0902-0063

Abstract

<abstract abstract-type="main" id="ctr12245-abs-0001"> <title>Abstract</title> <sec id="ctr12245-sec-0001" sec-type="section"> <title>Objective</title> <p>To review the incidence and long‐term outcomes of squamous cell carcinoma (SCC) of the bladder in patients after kidney transplantation.</p> </sec> <sec id="ctr12245-sec-0002" sec-type="section"> <title>Methods</title> <p>Between January 1976 and March 2013, five patients from one center (0.0013%) developed SCC of the bladder after undergoing a deceased donor kidney transplant. Their relevant risk factors included long‐term self‐intermittent catheterization/indwelling catheter (n = 2), smoking history (n = 2), and a prior history of cyclophosphamide treatment for vasculitis (n = 1). Primary outcome variables were overall patient survival and latency period between transplantation and SCC diagnosis.</p> </sec> <sec id="ctr12245-sec-0003" sec-type="section"> <title>Results</title> <p>The duration of long‐term follow‐up was 94 ± 89 (range: 4–239) months. The latency period between transplantation and bladder SCC was 87 ± 87 (range: 2–228) months, and all five patients were immunosuppressed with tacrolimus, mycophenolate mofetil, and prednisone. Four patients had suspected metastases upon presentation, and one patient presented with organ‐confined disease. This patient underwent a radical cystectomy and remains disease free eight months post‐operatively. Despite radical treatment, the remaining four patients died from metastatic disease 7 ± 4.4 (range: 2–11) months after their initial diagnosis.</p> </sec> <sec id="ctr12245-sec-0004" sec-type="section"> <title>Conclusion</title> <p>SCC of the bladder has a poor prognosis particularly in renal transplant patients. Early detection with flexible cystourethroscopy in patients with risk factors for SCC may improve long‐term outcomes in this patient cohort.</p> </sec> </abstract>