Expression of programmed death‐1 (CD279) in primary cutaneous B‐cell lymphomas with correlation to lymphoma entities and biological behaviour. (December 2013)

• Record Type: Journal Article
• Authors: Mitteldorf, C.; Bieri, M.; Wey, N.; Kerl, K.; Kamarachev, J.; Pfaltz, M.; Kutzner, H.; Roncador, G.; Tomasini, D.; Kempf, W.
• Is Part Of: British journal of dermatology. Volume 169:Number 6(2013:Dec.)
• Page Start: 1212
• Page End: 1218
• Publication Date: 2013-12
• Subjects: Dermatology -- Periodicals; Skin -- Diseases -- Periodicals; 616.5
• DOI: 10.1111/bjd.12579
• Languages: English
• ISSNs: 0007-0963

Abstract

<abstract abstract-type="short" xml:lang="en" id="bjd12579-abs-0002"> <title> <x xml:space="preserve">Abstract</x> </title> <p> <bold>What's already known about this topic?</bold> </p> <p> <list id="bjd12579-list-0001" list-type="bullet"> <list-item> <p>In nodal follicular lymphoma, the number of intratumoral programmed death (PD)‐1‐positive lymphocytes is associated with overall survival. No data exist for primary cutaneous B‐cell lymphoma (PCBCL).</p> </list-item> </list> </p> <p> <bold>What does this study add?</bold> </p> <p> <list id="bjd12579-list-0002" list-type="bullet"> <list-item> <p>A higher number of PD‐1‐expressing cells was found in indolent primary cutaneous marginal zone lymphoma and primary cutaneous follicle centre lymphoma, in contrast to the more aggressive diffuse large B‐cell lymphoma, leg type.</p> </list-item> <list-item> <p>PD‐1‐positive cells do not represent only follicular helper T cells.</p> </list-item> <list-item> <p>The tumour cells in all investigated types of PCBCL did not show aberrant PD‐1 expression.</p> </list-item> </list> </p> </abstract>