Lower risk of atopic dermatitis among infants born extremely preterm compared with higher gestational age. (December 2013)

• Record Type: Journal Article
• Authors: Barbarot, S.; Gras‐Leguen, C.; Colas, H.; Garrot, E.; Darmaun, D.; Larroque, B.; Roze, J.C.; Ancel, P.Y.
• Is Part Of: British journal of dermatology. Volume 169:Number 6(2013:Dec.)
• Page Start: 1257
• Page End: 1264
• Publication Date: 2013-12
• Subjects: Dermatology -- Periodicals; Skin -- Diseases -- Periodicals; 616.5
• DOI: 10.1111/bjd.12581
• Languages: English
• ISSNs: 0007-0963

Abstract

<abstract abstract-type="main" id="bjd12581-abs-0001"> <title>Summary</title> <sec id="bjd12581-sec-0001" sec-type="section"> <title>Background</title> <p>It is not yet known whether the risk of developing atopic dermatitis (AD) is influenced by preterm birth. Moreover, AD risk has not been assessed in a large sample of extremely preterm infants (< 29 weeks' gestation).</p> </sec> <sec id="bjd12581-sec-0002" sec-type="section"> <title>Objectives</title> <p>To determine whether the risk of AD is influenced by preterm birth.</p> </sec> <sec id="bjd12581-sec-0003" sec-type="section"> <title>Methods</title> <p>We investigated the relationship between gestational age (GA) and AD using data from two independent population‐based cohorts, including a total of 2329 preterm infants, of whom 479 were born extremely preterm.</p> </sec> <sec id="bjd12581-sec-0004" sec-type="section"> <title>Results</title> <p>There was a lower percentage of children with AD in the extremely preterm group compared with those born at a greater GA (Epipage cohort, 2‐year outcome: 13·3% for 24–28 weeks, 17·6% for 29–32 weeks, 21·8% for 33–34 weeks, <italic>P </italic>=<italic> </italic>0·02; LIFT cohort, 5‐year outcome: 11% for 24–28 weeks, 21·5% for 29–32 weeks, 19·6% for 33–34 weeks, <italic>P </italic>=<italic> </italic>0·11). After adjusting for confounding variables, a lower GA (< 29 weeks) was significantly associated with decreased risk of AD in the Epipage cohort [adjusted odds ratio (aOR) 0·57, 95% confidence interval (CI) 0·37–0·87; <italic>P </italic>=<italic> </italic>0·009] and the LIFT cohort (aOR 0·41, 95% CI 0·18–0·90; <italic>P </italic>=<italic> </italic>0·03).</p> </sec> <sec id="bjd12581-sec-0005" sec-type="section"> <title>Conclusions</title> <p>Very low GA (< 29 weeks) was associated with a lower risk of AD compared with higher GA (29–34 weeks) and full‐term birth.</p> </sec> </abstract>